Effectiveness of a Culturally Adapted Mindfulness-Based Intervention on Blood Pressure, Medication Adherence, and Self-Management: A Quasi-Experimental Study
DOI:
https://doi.org/10.55018/janh.v8i2.427Keywords:
Hypertension, Mindfulness, Medication adherence, Self-care, Nursing, IndonesiaAbstract
Background: Hypertension is a leading global health problem, with poor adherence to treatment remaining a major barrier to effective control. Mindfulness has emerged as a supportive strategy for improving adherence and self-care. However, the effectiveness in non-Western hypertensive populations remains unclear. This study aimed to evaluate the effectiveness of a culturally adapted mindfulness intervention on blood pressure, medication adherence, and self-care in patients with hypertension in Indonesia.
Methods: A nonrandomized quasi-experimental pretest-posttest control group design was employed. 40 adults aged 18-40 years with stage 1 hypertension were recruited through purposive sampling, and the minimum sample size was determined using power analysis (G*Power 3.1), resulting in a minimum of 15 participants per group. To account for attrition, 20 participants were recruited per group. We excluded adults with coronary heart disease, pregnancy, concurrent complementary therapies, or prior mindfulness experience. The study followed the TREND guideline for nonrandomized evaluations. Participants were allocated to an intervention group (n = 20) that received an eight-week culturally adapted mindfulness program delivered in group and individual sessions, or to a control group (n = 20) that received standard care. Data were collected at baseline, post-intervention, and one-month follow-up, using a validated digital sphygmomanometer (blood pressure), the Morisky Medication Adherence Scale-8 (medication adherence), and the Self-Care of Hypertension Inventory (self-care). Ethical clearance was obtained from the institutional review board (No. 109/VII/AUEC/2024), and data were analysed using repeated-measures ANOVA and independent t-tests.
Results: Participants in the intervention group experienced significant reductions in systolic and diastolic blood pressure and improved medication adherence compared with the control group, with effects sustained at follow-up (time x group interaction: SBP F = 8.33, p < 0.001, η² = 0.15; DBP F = 7.01, p = 0.002, η² = 0.13; MMAS-8 F = 15.27, p < 0.001, η² = 0.24). Self-care scores increased significantly post-intervention (p = 0.030) but declined at follow-up, with no significant group difference at T2 (p > 0.05). Baseline characteristics were comparable between groups, ensuring equivalence.
Conclusion: A culturally adapted mindfulness program effectively improved blood pressure control and medication adherence in Indonesian patients with hypertension, although self-care benefits diminished over time. These findings suggest that mindfulness-based interventions can be a feasible, low-cost complement to standard care, particularly in resource-limited settings. Future studies with larger samples, longer follow-up, and reinforcement strategies are recommended to sustain self-care behaviours.
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References
Abdul Manan, H., Mir, I. A., Humayra, S., Tee, R. Y., & Vasu, D. T. (2024). Effect of mindfulness-based interventions on anxiety, depression, and stress in patients with coronary artery disease: A systematic review and meta-analysis of randomized controlled trials. Frontiers in Psychology, 15, 1435243. https://doi.org/10.3389/fpsyg.2024.1435243
Albarracín, D., Fayaz-Farkhad, B., & Granados Samayoa, J. A. (2024). Determinants of behaviour and their efficacy as targets of behavioural change interventions. Nature Reviews Psychology, 3(6), 377–392. https://doi.org/10.1038/s44159-024-00305-0
American Heart Association. (2023). Understanding Blood Pressure Readings _ American Heart Association. https://www.heart.org/en/health-topics/high-blood-pressure/understanding-blood-pressure-readings
Benenson, I., Waldron, F. A., Jadotte, Y. T., Dreker, M. (Peggy), & Holly, C. (2021). Risk factors for hypertensive crisis in adult patients: A systematic review. JBI Evidence Synthesis, 19(6), 1292–1327. https://doi.org/10.11124/JBIES-20-00243
Burnier, M., & Damianaki, A. (2023). Hypertension as Cardiovascular Risk Factor in Chronic Kidney Disease. Circulation Research, 132(8), 1050–1063. https://doi.org/10.1161/CIRCRESAHA.122.321762
Chen, Q., Liu, H., & Du, S. (2024). Effect of mindfulness-based interventions on people with prehypertension or hypertension: A systematic review and meta-analysis of randomized controlled trials. BMC Cardiovascular Disorders, 24(1), 104. https://doi.org/10.1186/s12872-024-03746-w
Cipta, D. A., Andoko, D., Theja, A., Utama, A. V. E., Hendrik, H., William, D. G., Reina, N., Handoko, M. T., & Lumbuun, N. (2024). Culturally sensitive patient-centered healthcare: A focus on health behavior modification in low and middle-income nations—insights from Indonesia. Frontiers in Medicine, 11, 1353037. https://doi.org/10.3389/fmed.2024.1353037
Conversano, C., Orrù, G., Pozza, A., Miccoli, M., Ciacchini, R., Marchi, L., & Gemignani, A. (2021). Is Mindfulness-Based Stress Reduction Effective for People with Hypertension? A Systematic Review and Meta-Analysis of 30 Years of Evidence. International Journal of Environmental Research and Public Health, 18(6), 2882. https://doi.org/10.3390/ijerph18062882
Direktorat Promosi Kesehatan dan Pemberdayaan Masyarakat Kementerian Kesehatan RI. (2022, January 14). Perilaku CERDIK dalam Mencegah Penyakit Tidak Menular. https://promkes.kemkes.go.id/perilaku-cerdik-dalam-mencegah-penyakit-tidak-menular
Eldawati, E., Said, F. M., & Umar, N. S. (2022). Cross-cultural Adaptation, Validity and Reliability of the Indonesian Version of the Self-care of Hypertension Inventory Scale. Malaysian Journal of Medicine and Health Sciences, 18(SUPP17), 302–309. http://dx.doi.org/10.11591/ijphs.v14i3.23685
Fan, L., & Cui, F. (2024). Mindfulness, self-efficacy, and self-regulation as predictors of psychological well-being in EFL learners. Frontiers in Psychology, 15, 1332002. https://doi.org/10.3389/fpsyg.2024.1332002
Hamrahian, S. M., Maarouf, O. H., & Fülöp, T. (2022). A Critical Review of Medication Adherence in Hypertension: Barriers and Facilitators Clinicians Should Consider. Patient Preference and Adherence, Volume 16, 2749–2757. https://doi.org/10.2147/PPA.S368784
Irawan AM, A., Anwar, S., Anggraini, D., & Khasanah, U. (2024). Efectiveness of Mindfulness in Alleviating Hypertension and Anxiety in Adults Patients. Jurnal Aisyah : Jurnal Ilmu Kesehatan, 9(2), 1014–1021. https://doi.org/10.30604/jika.v9i2.2836
Irawan AM, A., Janmabhumi, A., Wulandari, Z. A., Putri, A. P., & Santoso, A. P. A. (2023). Effect Of Mindfulness Based Cognitive Therapy (MBCT) on Anxiety and Blood Pressure for Hypertension: A scoping review. Citra Delima Scientific Journal of Citra Internasional Institute, 7(2), 120–127. https://doi.org/10.33862/citradelima.v7i2.379
Irawan AM, A., Janmabhumi, A., Wulandari, Z. A., Santoso, A. P. A., & Putri, A. P. (2023). A Delphi Consensus of Mindfulness-Based Cognitive Therapy for managing anxiety and blood pressure in hypertensive patient. International Journal of Nursing and Health Services (IJNHS, 6(5), 323–328. https://doi.org/DOI: 10.35654/ijnhs.v6i5.762
Kementerian Kesehatan RI. (2020, June). Profil Kesehatan indonesia 2019. Kementerian Kesehatan RI.
Kementerian Kesehatan RI. (2024, January 31). Laporan Kinerja 2023 Direktorat Pencegahan dan Pengendalian Penyakit Menular. Kementerian Kesehatan RI. https://p2p.kemkes.go.id/wp-content/uploads/2024/02/Lapkin-2023-P2PM_16022024.pdf
Lee, E. K. P., Yeung, N. C. Y., Xu, Z., Zhang, D., Yu, C.-P., & Wong, S. Y. S. (2020). Effect and Acceptability of Mindfulness-Based Stress Reduction Program on Patients With Elevated Blood Pressure or Hypertension: A Meta-Analysis of Randomized Controlled Trials. Hypertension, 76(6), 1992–2001. https://doi.org/10.1161/HYPERTENSIONAHA.120.16160
Li, J., Xu, C., Wan, K., Liu, Y., & Liu, L. (2023). Mindfulness-based interventions to reduce anxiety among Chinese college students: A systematic review and meta-analysis. Frontiers in Psychology, 13, 1031398. https://doi.org/10.3389/fpsyg.2022.1031398
Li, W. W., McIntyre, R., Reid, C., & Chao, M. (2024). A Systematic Review on the State of the Art of Culturally Adapted Mindfulness-Based Interventions for First Nations Peoples: Cultural Adaptation, Effectiveness, and Feasibility. Mindfulness, 15(9), 2147–2172. https://doi.org/10.1007/s12671-024-02440-4
Loucks, E. B., Kronish, I. M., Saadeh, F. B., Scarpaci, M. M., Proulx, J. A., Gutman, R., Britton, W. B., & Schuman-Olivier, Z. (2023). Adapted Mindfulness Training for Interoception and Adherence to the DASH Diet: A Phase 2 Randomized Clinical Trial. JAMA Network Open, 6(11), e2339243. https://doi.org/10.1001/jamanetworkopen.2023.39243
Miles, E., Matcham, F., Strauss, C., & Cavanagh, K. (2023). Making Mindfulness Meditation a Healthy Habit. Mindfulness, 14(12), 2988–3005. https://doi.org/10.1007/s12671-023-02258-6
Morisky, D. E., Ang, A., Krousel‐Wood, M., & Ward, H. J. (2008). Retracted: Predictive Validity of a Medication Adherence Measure in an Outpatient Setting. The Journal of Clinical Hypertension, 10(5), 348–354. https://doi.org/10.1111/j.1751-7176.2008.07572.x
Muniyandi, M., Sellappan, S., Chellaswamy, V., Ravi, K., Karthikeyan, S., Thiruvengadam, K., Selvam, J. M., & Karikalan, N. (2022). Diagnostic accuracy of mercurial versus digital blood pressure measurement devices: A systematic review and meta-analysis. Scientific Reports, 12(1), 3363. https://doi.org/10.1038/s41598-022-07315-z
Nardi, W. R., Loucks, E. B., Springs, S., Operario, D., Kronish, I. M., Gaudiano, B. A., & Sun, S. (2021). Mindfulness-based interventions for medication adherence: A systematic review and narrative synthesis. Journal of Psychosomatic Research, 149, 110585. https://doi.org/10.1016/j.jpsychores.2021.110585
Ojangba, T., Boamah, S., Miao, Y., Guo, X., Fen, Y., Agboyibor, C., Yuan, J., & Dong, W. (2023). Comprehensive effects of lifestyle reform, adherence, and related factors on hypertension control: A review. The Journal of Clinical Hypertension, 25(6), 509–520. https://doi.org/10.1111/jch.14653
Ponte Márquez, P. H., Feliu-Soler, A., Solé-Villa, M. J., Matas-Pericas, L., Filella-Agullo, D., Ruiz-Herrerias, M., Soler-Ribaudi, J., Roca-Cusachs Coll, A., & Arroyo-Díaz, J. A. (2019). Benefits of mindfulness meditation in reducing blood pressure and stress in patients with arterial hypertension. Journal of Human Hypertension, 33(3), 237–247. https://doi.org/10.1038/s41371-018-0130-6
Pukdeesamai, R., Srihatrai, P., & Intarut, N. (2023). Effects of a Mindfulness Meditation on Blood Pressure in Prehypertension Patients: A Randomized Controlled Trial. Journal of the Medical Association of Thailand, 106(9), 843–848. https://doi.org/10.35755/jmedassocthai.2023.09.13886
Riani, D. A., Ikawati, Z., & Kristina, S. A. (2017). Validasi 8-item Morisky Medication Adherence Scale versi Indonesia pada pasien hipertensi dewasa di Puskesmas Kabupaten Sleman dan Kota Yogyakarta [Gajah Mada University]. https://etd.repository.ugm.ac.id/penelitian/detail/109818
Sawyer, H. (2023). Mindfulness: Strategies to implement targeted self-care. Journal of Interprofessional Education & Practice, 31, 100614. https://doi.org/10.1016/j.xjep.2023.100614
Shahbabu, B. (2016). Which is More Accurate in Measuring the Blood Pressure? A Digital or an Aneroid Sphygmomanometer. Journal Of Clinical and Diagnostic Research. https://doi.org/10.7860/JCDR/2016/14351.7458
Suleiman, S. Z., Htay, M. N. N., Soe, H. H. K., Low, C. L. Y., Alias, S. H., Yussof, S., Keng, W. X., Chong, K., Sahiran, M. F., Harun, M. H., Othman, A., Abdullah, R., Mansor, N. M., Ishak, N. H., Abdul Rahman, A. F. A., & Moe, S. (2024). Association between medication adherence and blood pressure control and factors associated with antihypertensive medication adherence in the Melaka Tengah District: A cross-sectional survey. Malaysian Family Physician, 19, 56. https://doi.org/10.51866/oa.651
Sulosaari, V., Unal, E., & Cinar, F. I. (2022). The effectiveness of mindfulness-based interventions on the psychological well-being of nurses: A systematic review. Applied Nursing Research, 64, 151565. https://doi.org/10.1016/j.apnr.2022.151565
Suwanno, J., Phonphet, C., Thiamwong, L., Mayurapak, C., & Ninla-aesong, P. (2022). Evaluating the Dimensionality and Reliability of the Thai Self-Care of Hypertension Inventory Version 2.0. Asian Nursing Research, 16(4), 197–207. https://doi.org/10.1016/j.anr.2022.08.002
Tanjung, M. R. H. (2024). Applying Of Mindfulness-Based Stress Reduction (MBSR) Method To Reduce Anxiety Level In Pregnant Women With Gestational Hypertension: A Randomized Control Trial. Jurnal Eduhealth, 15(02). https://ejournal.seaninstitute.or.id/index.php/healt
Valley, M., & Stallones, L. (2018). A Thematic Analysis of Health Care Workers’ Adoption of Mindfulness Practices. Workplace Health & Safety, 66(11), 538–544. https://doi.org/10.1177/2165079918771991
WHO. (2023). Hypertension. Hypertension. https://www.who.int/news-room/fact-sheets/detail/hypertension
Zhang, J., Hu, J., Zheng, Y., & Dai, T. (2025). Factors affecting medication adherence in patients with chronic diseases: A systematic literature review. Chinese General Practice Journal, 2(3), 100072. https://doi.org/10.1016/j.cgpj.2025.100072
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